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Several PARP inhibitors have reached clinical trial testing for treatment in different cancers, and, recently, Olaparib (AZD2281) has gained both United States Food and Drug Administration (USFDA) and the European Commission (EC) approval for use in BRCA-mutated advanced ovarian cancer treatment. We describe two unrelated patients with terminal deletions in the long arm of chromosome 13 showing brain malformation consisting of holoprosencephaly and cerebellar vermis hypoplasia. Gene transfer techniques such as electroporation and lipofection are powerful systems for investigating gene function. They are also consistent with previous research showing that not all children prefer to imitate following direct reinforcement of other imitative behavior.

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