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Spiractin (Spironolactone)

Spiractin is a synthetic 17-Spiractin corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities. Spiractin competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. Check for active clinical trials using this agent.

Other names for this medication:
Spironolactone, Aldactone, Aldactazide, Aldactazine, Aldazida, Aldazide, Aldozone, Alexan, Alizar, Carpiaton, Espirone, Espironolactona, Expal, Kespirona, Lanx, Letonal, Osiren, Osyrol, Practon, Prilactone, Spiractin, Spiresis, Spirix, Spiroctan, Spirolang, Spirolon, Spiron, Spirono, Spironolacton, Spironolactona, Spironolakton, Spironolattone, Spirotone, Verospiron, Xenalon,

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However, neither anti-bFGF nor anti-PDGF abrogated the stimulation of tumor cells by normal mammary epithelial cells or normal mammary stromal cell. Future research should assess the implications of cumulative exposures to environmental and social stressors for regulatory decision-making. Labor mobility, trade and structural change: the Philippine experience.

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Functional MRI and DT-MRI, together with MPRAGE and T2w structural MRI were acquired at 3 T prior to surgery. MMN was obtained for both repetition and ITD deviants, occurring at 150 ms and 100 ms after stimulus onset respectively. The prevalence, severity, and time course of mucosal abnormalities were analyzed, as judged by consecutive computed tomographies (CTs). Trends and patterns of population concentration in the Czech Socialist Republic for the period 1869-1970 are examined, with a focus on the relationship between changes in population concentration and employment opportunities. Though a temporary improvement was observed, interstitial pneumonitis relapsed and the patient died of respiratory failure and liver dysfunction.

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Such results suggest that acute RE promotes enhanced insulin-induced vasodilatation, which could act as a fine tuning to vascular tone. Oxygen effects of metabolism and paraquat uptake in rat lung slices. Using a repeated acquisition procedure in a 3-panel runway apparatus, the effect of WEB 1881 FU on impairment of working memory produced either by scopolamine or by cerebral ischemia was investigated in rats and compared with those of aniracetam and Ca hopantenate.

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The phenotypical, biochemical and proteome data show that the single-wavelength laser light is suitable for plant growth and therefore, potentially able to unlock the advantages of this next generation lighting technology for highly energy-efficient horticulture. Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4. Furthermore, also for the first time, it was possible to demonstrate in a direct comparison, the role played by donor versus recipient characteristics on the olfactory composition of the recipients odor. Three groups of 10 men of low selenium status were given 200 micrograms Se/day as Serich wheat, Se-rich yeast, or sodium selenate for 11 wk.

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Orthotopic liver transplantation in knockout mice: is TNFalpha involved in early graft injury and regeneration? It did not cause any change in cardiac output, heart rate or systemic vascular resistance, whereas the pulmonary wedge, mean pulmonary and right atrial pressures and pulmonary blood volume fell progressively, the difference from the control values being significant 5 minutes after the injection.

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The aim of this study was to investigate the capability of phenazine dioxides, recognized bioreductive antitumour agents, as carriers for (99m)Tc in order to generate potential theranostic radiopharmaceuticals towards hypoxic solid tumours. Relationship between the phase value of ESWAN and fractional anisotropy of diffusion tensor imaging in patients with cerebral microbleeds: preliminary results. Patients who develop pancreatitis may be able to tolerate therapy with a lower dose after resolution of their symptoms. If EEG under exercising can be measured, we can assess the mental condition of the athlete. Improving participation in colorectal cancer screening: targets for action.

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Mutations affecting the expression of dystrophin result in progressive loss of skeletal muscle function and cardiomyopathy leading to early mortality. The indications for parenteral nutrition (nutrition support and hyperalimentation) in gastro-intestinal surgery, traumatology and burn care are discussed.

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Re: Long-term results of small intestinal submucosa graft in bulbar urethral reconstruction. In contrast, severe oligospermia was noted among four men evaluated during and immediately after treatment.

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Indications and results of cytostatic therapy in gastrointestinal tumors Susceptibility test results from 100 clinical isolates, using the AMS, MS-2, Autobac MTS, Micro-Media system, and Sensititre, were compared with results from the proposed National Committee for Clinical Laboratory Standards reference microdilution method for minimum inhibitory concentrations and with Bauer-Kirby results. In recent years it has become possible to use eggs from one woman to bring about a pregnancy in another. Absent pulmonary valve syndrome (APVS) is a rare congenital heart defect, usually associated with tetralogy of Fallot (TOF), although other associations have been described. It is concluded that exercise training does not stimulate the multiplication of cardiac capillaries.

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In clinical practice, this dependence may cause significant measurement variability that can be reduced by specific measurement maneuvers. Multivariate analysis of mainstream tobacco smoke particulate phase by headspace solid-phase micro extraction coupled with comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry. Analytical frameworks for such analysis exist but are infrequently used in road safety because the evidence base on AADT uncertainty is not well developed. For this reason, echinostomes have served for years as experimental models in different areas of parasitology. Newer technology accommodating IOLs in development have embraced design strategies using dual optics, shape-changing optics, and IOLs with dynamic changes in refractive index.

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Six and 12 months postoperatively, PCO was evaluated by retroillumination photographs using Evaluation of Posterior Capsule Opacification (EPCO) 2000 image-analysis software. Female heads assumed more farming responsibilities and had higher remittances from husbands.

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Reinforcing, subjective, and psychomotor effects of sevoflurane and nitrous oxide in moderate-drinking healthy volunteers. Catecholamine release induces elevation in plasma lactate levels in patients undergoing adrenalectomy for pheochromocytoma. We report a patient with tuberculous meningitis who continued to have persistent fever despite the satisfactory treatment of her tuberculosis. Microbial culture and susceptibility testing of tissue samples indicated the presence of multidrug-resistant Staphylococcus pseudintermedius.

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These deficits were were antagonized by repeated stressor application or by desmethylimipramine. We calculated corresponding femoral/tibial lengths at gestational weeks 20 and 30. Ten microsatellite DNA loci developed for the white-toothed shrew (Crocidura russula) were tested for PCR amplification and for utility in linkage studies in the house musk shrew, Suncus murinus. The importance of redox control in nodule development and N-fixation is discussed in this review.

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As such, oncology clinicians will have to carefully review and update their management approaches accordingly even as they begin to focus even more on the survivorship needs of their MM patients. tsugae feeding also decreased mechanical strength and flexibility in currently attacked twigs, but this effect disappeared in older, previously attacked branches. Based on neurological finding, he was diagnosed as having ataxic hemiparesis with ipsilateral cheiro-oral syndrome.

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We report herein a case of familial neurilemmomatosis seen in a 16-year-old girl and her 38-year-old mother. Protein kinase C (PKC) is the major cellular receptor for tumor promoting phorbol esters. The largest funding flows are directed at ophthalmology, followed by cleft lip and palate surgery.

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Turbidimetric determination of gamma globulins after precipitation by heparin and cobaltous chloride The ALP isoenzymes in PF from 10 clinically normal horses and from 50 horses with clinical signs of acute abdominal pain were analyzed for their sensitivities to inhibition by L-phenylalanine, L-homoarginine, and levamisole and to inactivation by heat (56 C, 15 minutes). It is well established that mechanical loading is important to homeostasis of cartilage tissue, and growing evidence suggests that it influences cartilage differentiation as well. In two patients graft-versus-host disease developed and was treated by immunosuppression.

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Grain soluble sugar content response to drought was not affected in Suyunuo5 but was decreased in Yunuo7. Spatial-processing ability, as measured by the spatial advantage measure of the LiSN-S, was negatively affected by hearing impairment. By electron microscopy, membrane deposited, pore-like lesions are detected on the target cell membrane during cytolysis by CTL.

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Polyethylene terephthalate bottles (PRBs): a health and safety assessment. Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects. At 4 years, besides clinical routine laxity tests, varus/valgus rotation, internal/external tibial rotation, initial and endpoint valgus stiffnesses, initial and endpoint internal/external rotational stiffnesses were measured by instrumented computerized passive motion analysis (Genucom). Chiral helicenoid diarylethene with large change in specific optical rotation by photochromism.

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We thus conducted this meta-analysis, aimed at clarifying whether rTMS enhances the efficacy of TRD. The potential of RNAi is especially relevant in cancer therapy, as it can be designed to regulate the expression of genes involved in all stages of tumor development (initiation, growth, and metastasis).

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In patients with MCC, 18F-FDG PET or PET/CT demonstrated high sensitivity and specificity, being accurate methods in this setting. We concluded that the normalization of the slow atrial rate decreased FAZ in patients with SSS and may be helpful in preventing atrial tachyarrhythmia in some patients with SSS. A comparison was performed of three small-gauge, permanent, rare-earth, intraocular magnets to assist the posterior segment surgeon with the decision as to which magnet to purchase or to use in different clinical situations. To evaluate weekly subcutaneous albiglutide versus daily sitagliptin in renally impaired patients with type 2 diabetes and inadequately controlled glycemia on a regimen of diet and exercise and/or oral antihyperglycemic medications. In complementary studies, dexamethasone mediated changes in tumor capillary permeability, tumor water distribution, relative tumor blood flow and tumor cell proliferation were also determined.

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However, recent results monitoring the cleavage rate of PAR-1 on human umbilical vein endothelial cells, transfected with an alkaline phosphatase-PAR-1 fusion reporter construct, have indicated that the catalytic activity of thrombin toward PAR-1 is several orders of magnitude higher than that of APC. Odorous gaseous emissions as influence by process condition for the forced aeration composting of pig slaughterhouse sludge. Here, we review our current understanding of ribonucleoprotein complexes, including RBPs and miRNAs, which play critical roles in the acquisition of drug resistance and have potential clinical implications for cancer. Clinical and pathogenetic features in 65 cases of erythema nodosum

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Use of digital media technology for primary prevention of STIs/HIV in youth. None of the investigated energy parameters correlated with the protective effects. People with preexisting health problems may desire to visit high altitude destinations. Twenty-four hours following lesion, plasma membrane staining of eN-CAM on both axons and dendrites had increased in intensity within the OML, whereas membrane eN-CAM staining was diminished in the inner molecular layer (IML), and the intradendritic cytoplasmic staining disappeared.

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Effect of some sugars and polyols on the kinetics of sorbitol dehydrogenase. Cancer/testis antigen HCA587-derived long peptide vaccine generates potent immunologic responses and antitumor effects in mouse model. To our knowledge, this is the first case report to document that, with similar medications, a previous skin response to a given radiotherapy dose, fraction, and technique may not be predictive of subsequent skin response to similar radiotherapy.

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The preliminary study shows that the nonenzymatic sensor has synergistic electrocatalytic activity to the oxidation of glucose in alkaline media. Two cultured human mesenchymal stem cell samples were used as controls. The perceptual coding method revealed that pitch range, length of utterance, and total amount of sound significantly discriminated sarcastic from non-sarcastic utterances. To test the hypothesis that inflammatory cytokine production might be an early event in the development of the disease associated with smoking, we used alveolar cells from healthy nonsmokers stimulated with TGP as a model system. Electroencephalographic responses in dogs during reduced blood flow.

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Children were at high risk for TB disease when the index case started MDR-TB treatment and during the following year. Loeys-Dietz syndrome (LDS) is a recently recognized connective tissue disorder (CTD) caused by mutations in transforming growth factor-beta receptor (TGFBR)1 and TGFBR2. Latex allergy first was recognized early in the 20th Century, but was not a matter of concern until the last decade of that Century.

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It is difficult to excise completely using a wide local excision. The inverse-reconstructed epicardial potentials were compared to the actual measured potentials throughout a normal cardiac cycle. The 2010 combined bleaching and Caribbean yellow band disease outbreak in Puerto Rico provided a unique opportunity to investigate the spectral signatures associated with bleached and Caribbean yellow band-diseased colonies of Orbicella faveolata for the first time. Larger portion of literature accounts for experimental investigations, which is a sign of the preference for hands-on work by experimentalists. Masumi Hinohara who has worked as a public health nurse in an isolated island for the past 30 years

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Success factors of hospital information system implementation: what must go right? The progestogenic component of OCs does not appear to influence the risk of venous thromboembolism. Structural investigations of membrane proteins: the versatility of electron microscopy.

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The aim of this study was to investigate the prevalence of congenital CMV infection among children with autism spectrum disorder (ASD) in Nagasaki, Japan. Importance and tactical use of the Institute of Drug Examination of DDR Typically, this emission is from the initially excited state of the fluorophore (F). Perceived job insecurity and health: the Michigan Recession and Recovery Study.

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Furthermore, influenza protein expression induces activation of IkappaB kinase (IKK). The asymmetry was found to have a statistically significant trend to left side both of the control and the variants of treatment. This article reviews the verbal and physical abuse that threatens the well-being and physical survival of lesbian, gay male, and bisexual youths. In previous studies we demonstrated that treatment of tumor-bearing mice with a long-acting synthetic analogue of PGE2 (di-M-PGE2) stimulated the synthesis of endogenous prostaglandins. Intravenous immunoglobulin for severe sepsis and septic shock: clinical effectiveness, cost-effectiveness and value of a further randomised controlled trial.

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Application of 1 variety of permanent magnet had no effect on our small group of subjects with chronic low back pain. Stores of corticosterone in rat adrenals under different experimental conditions. In mitochondria from alpha-tocopherol-deficient rabbit hearts (30 days), there was a close correlation between the decline in respiration and the incidence of membrane peroxidation.

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We evaluated whether pancreatic main duct fluid can provide protein biomarkers with prognostic value. Whether to continue to exploit a source of reward, or to search for a new one of potentially greater value, is a fundamental and underconstrained decision. Effect of thyroxine on the swelling of mitochondria isolated from various tissues of the rat.

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Procedural mortality is low and morbidity at the implantation site typically moderate. This is followed by sections describing the animal experiments, incorporation rates of amphetamines from blood to hair and relationship between drug history and drug distribution in hair.

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Martin and Khafif defined specific criteria to confirm the diagnosis of primary branchiogenic carcinoma. After the spontaneous motility of the strips had reached a steady state the test substances PGF2 alpha and oxytocin were added to the bath at three different concentrations. However, this receptor also activates nuclear factor kappaB (NF-kappaB), the role of which has yet to be determined. Diabetic subjects with or without signs of autonomic neuropathy have a decreased vagal activity (and hence a relatively higher sympathetic activity) during night hours and at the same time of the day, during which a higher frequency of cardiovascular accidents has been reported.

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Using cell lines that vary in susceptibility to invasion, we confirmed and clarified the results of our in vivo studies by documenting three modes of interference: exclusion of larvae from cells, encumbrance of larvae as they migrated within epithelial monolayers, and inhibition of parasite development. rickettsii -induced increase in PAI-1 mRNA was blocked by the eukaryotic protein synthesis inhibitor, cycloheximide, which suggests that this response requires de novo host cell protein synthesis.

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The profile of ultrafiltrable (UF) Pt during successive haemodialysis cycles was striking. In this connection, we measured nitrite and nitrate (NO metabolites), ischaemia-modified albumin (IMA) and thiobarbituric acid-reactive substances (TBARS) in patients with ischaemic stroke. Using a meta-analytic Bayes factor approach, we found that the gaming condition that emphasized maintenance and rapid switching between multiple information and action sources led to a large increase in cognitive flexibility as measured by a wide array of non-video gaming tasks. Stable dyes containing double acceptors without COOH as anchors for highly efficient dye-sensitized solar cells.

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After demonstrating constant recovery rates, ICLNs from 540 pigs were examined for Salmonella spp. With increasing rate (decreasing MPI), there were increases in peak latencies, increases in the i-iv interval, and decreases in peak amplitudes. Here we also confirmed that distribution of kinesin NACK1 is not the cause of cytokinesis defect. We determined that the antibody response to OspA and OspB after natural infection of hamsters is similar to that seen esomeprazole tad 40 mg erfahrungen vital maxx in humans, and differs from the antibody response after hamster infection by needle inoculation. All participants were screened for cervical cancer by Pap smear and VIA.

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We investigated the expression of MMP-2 and -9, zentius side effects and the role of the TIMP-3 in MMP-2 activation, using cultures of cortical neurons and astrocytes. 2) At E14, intraepithelial GAP-43-immunoreactive fine nerves were first observed along the medial border of the palatal shelves which became several layers thick but still separate along their entire length. Prognosis and treatment of symptomatic hyponatremia--a study of 28 intensive care cases Epinephrine control of glycogen metabolism in glycogen-associated protein phosphatase PP1G/R(GL) knockout mice. Sodium glutamate had no effect on contractile responses of isolated papillary muscles at any of the concentrations used.

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The mRNA expression of Lsi1 medacin t gel in all wild rice species was lower than that in the cultivated rice, whereas the expression of Lsi2 was lower in O. Our scheme also generates a large synthetic magnetic field for the dressed spin state, which may facilitate the study of the quantum Hall effect in ultracold atomic gases. It was found that (-)-epigallocatechin gallate, (-)-epigallocatechin, and (-)-epicatechin gallate inhibited soybean lipoxygenase at the IC50 values ranging from 10 to 20 microM. Heparin binding and protease inhibitor activity of chemically modified antithrombin III.

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To determine whether granulocyte colony-stimulating factor (G-CSF) could prevent loss of spermatogenesis induced by busulfan chemotherapy via protection of undifferentiated spermatogonia, which might serve as an adjuvant approach to preserving male fertility among cancer patients. Subsequently, a secondary bifurcation gives rise to an oscillation with an incommensurable stemzine prochlorperazine tablets 5mg xanax frequency with respect to the former one. Alterations in REM and arousals characterized PTSD in this sample.

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A typical scenario is a stairway with a stair wall where the RANSAC plane-fitting procedure results in inliers patches in the tread, riser, and stair wall planes. Inhibition of the dimorphic transition of Candida albicans by the ornithine decarboxylase inhibitor 1,4-diaminobutanone: alterations in the glycoprotein composition of the cell wall. All patients were evaluated pre-operatively, and after 45th day (range 35-50 days) post-operatively. Importantly, mutations prevacid side effects lansoprazole dry throat disrupting the capacity of the ZnF2 to coordinate a Zinc ion unmask dTIS11 and TTP NLS and promote nuclear import. However, this figure could be further reduced if ERCP were performed only for therapeutic purposes by highly qualified endoscopy physicians.

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Expression of CRH and CRHR-1 was measured by real-time PCR in lesions and control skin. Knockdown of CD24 also suppressed the phosphorylation of Akt, which functions downstream of HER2 and PI3K to promote progen t20 vs entity xf gta cell survival. Clinical and radiographic features of moyamoya disease in patients with both cerebral ischaemia and haemorrhage. Effects of interleukin-4 or interleukin-10 gene therapy on trinitrobenzenesulfonic acid-induced murine colitis. There was no significant difference in PCR or serological responses between the study group and control group.

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Luteal phase-characteristic induction of I3SO3-GalCer in human cervical epithelia and uterine endometria, and follicular phase-characteristic formation of a ganglioside-derived negative charge gradient in different regions of fallopian tubes. The purpose of this study was to comprehensively review the literature addressing the physiological effects of hypothermia and megamox cv syrup its association with the appropriate core body temperature for extubation following coronary artery bypass surgery. Metabolites of orally administered Perilla frutescens extract in rats and humans.

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This paper describes the drusa di ametista ebay australia case of an 11 year old girl who presented with mixed connective tissue disease which was complicated by the development of pulmonary hypertension. The synthesis of densely functionalized N-heterocycles is an ongoing challenge in chemical synthesis.

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The arrow roxithromycin 150 mg wellbutrin viscoelastic behaviour of prototype composite orthodontic archwires was evaluated using a bend stress relaxation test. Other hindering factors included the lack of appropriate technology, the preference of the small privileged urban areas over the vast rural areas, the lack of the simultaneous approach in the development of water and sanitation and poor involvement of health education in the activities of the Water Decade. In controls at 18 mo, interstitial fibrosis was increased with respect to 3-mo-old rats, whereas myocytes dimension and the messenger RNA (mRNA) abundance of atrial natriuretic peptide (ANP), a2(I) procollagen, transforming growth factor (TGF-b1, TGF-b3), and secreted protein, acidic and rich in cysteine (SPARC) were not different. The effusions are exudates and not transudates as occurs in Demons-Meigs syndrome. The new double indicator dilution technique may be suitable for serial bedside CBF measurement.