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Scans from 30 patients (age range 11 months to 16 years, mean age 10 years 5 months) were included. Pretreatment with neutralizing antibodies to IL-1R or to IL-1alpha, but not to IL-1beta, markedly suppressed CFTR-172-induced EGFR-P and IL-8 production, suggesting that binding of IL-1alpha to IL-1R stimulates a TACE-EGFR-IL-8 cascade. Different features and conditions of the fertility transition in the developed countries and the developing countries
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