Griseofulvin is a metabolite of Penicillium griseofulvum and Penicillium janczewskii. It binds to and disrupts both the α and β tubulin subunits inducing conformational changes which disrupts the fungal mitotic spindle. As microtubules are involved in the transport of secretory material through the cytoplasm this has a profound cellular effect. As a consequence, Griseofulvin is a potent mutagen in multiple mammalian cell test assays. Griseofulvin is formulated as both microsize and ultramicrosize preparations given orally. In adults, the dose of the microsize preparation is 0.5–1 g daily administered once or twice daily. Microsize Griseofulvin should be administrated with a fatty food such as cheese or other dairy product, chocolate, fried food or nuts. The dosages of the ultramicrosize preparation are 330–660 mg daily. In children, the dose of microsize Griseofulvin is 10 mg/kg daily and for the ultramicrosize preparation 5.5 mg/kg daily.
Other names for this medication:
Griseofulvin,
Grifulvin,
Fulcin,
Fulvicin,
Fulviderm,
Fungistop,
Grifulin,
Grisetin,
Griseofulvina,
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