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Fulcover (Itraconazole)
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Itraconazole

Fulcover is triazole antifungal agent. As with other triazoles, it has five-membered ring structures containing three nitrogen atoms. It is available in oral capsule form (since 1992), oral solution in cyclodextrin (since 1997) and intravenous formulation in hydroxy-propyl-beta-cyclodextrin (since 1999). In its capsule and oral solution form, Fulcover is marketed as Fulcover by Janssen Pharmaceuticals. The intravenous formulation is marketed by Ortho Biotech. Fulcover is a highly lipophilic compound. While it achieves high concentrations in fatty tissues and purulent exudates, its penetration into aqueous fluids remains very limited. Gastric acidity and food influence the absorption of oral formulation.

Other names for this medication:
Itraconazole, Sporanox, Fulcover, Icoz, Candistat,

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It emphasizes the heterogeneity of studies and confirms that CDSSs can improve process measures but that evidence lacks for other types of outcomes, especially clinical or economic. Regulation of chicken apolipoprotein B: cloning, tissue distribution, and estrogen induction of mRNA.

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This adoptive transfer system has enabled us to provide direct proof for the participation of theta-bearing T lymphocytes in antibody responses of the IgE class. Furthermore, when the monooxygenase activities and SDS-polyacrylamide gel electrophoresis profiles of combined metal-treated animals were compared with those of the animals treated with classic inducers such as phenobarbital (75 mg/kg i.p., 72, 48 and 24 h prior to sacrifice) and 3-methylcholanthrene (20 mg/kg i.p., 72, 48 and 24 h prior to sacrifice), the combination of metals seemed to have tendency to stimulate certain phenobarbital and 3-methylcholanthrene inducible cytochrome P-450 isozymes. The extent to which this sensitivity change depends on hormones from the pituitary gland was investigated by implanting testosterone pellets into 15 hypophysectomized (pro- and mesoadenohypophysis) immature male lampreys. Constitutively activating mutations of the TSHR and LH/CGR (lutropin/choriogonadotropin receptor) are found in functional thyroid adenoma and familial male precocious puberty, respectively, and appear to be the direct cause of each disease. The land reform campaign of President Marcos has yet to recognize the need for land ownership.

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The two carriers of this hemoglobinopathy have different degrees of polyglobulia, since iron deficiency in one of them reduces total and abnormal Hb. The procedure can lead to subsequent surgical repair in a more favorable clinical status and has special significance in the low birth weight infant.

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The subtle energy transformations, bond-forming or bond-breaking, that were causing the two reactions of living matter to proceed in vitro forward or in reverse have been identified as the thermal work function delta Wto(T) and the chemical bond energy delta Ho0. Predeposit autologous blood transfusion in patients with colorectal cancer: a feasibility study.

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In conclusion, the ATF4 ODD may be useful for hypoxia-specific gene therapy by post-translational regulation of gene expression. The benefits and outcomes of the transplant outpatient unit were impressive.

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The transfer of genes into the germline of mice has become a standard technique of modern biomedical research. In 1987, Keratinomyces ceretanicus was reduced to synonymy with Trichophyton ajelloi based on mating between the putative ex-type culture, ATCC 58594, and minus mating strains of Arthroderma uncinatum. Our results establish HSP90 client recognition as a combinatorial process: CDC37 provides recognition of the kinase family, whereas thermodynamic parameters determine client binding within the family. Analysis of the slow phases of the in vivo chlorophyll fluorescence induction curve. The largest increase in demand came from respiratory problems, falls, and chest pains, with the largest decrease in calls from motor vehicle accidents.

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Enhanced antitumor efficacy of integrin-targeted oncolytic adenovirus AxdAdB3-F/RGD on bladder cancer. We assumed that with a stress duration of 15 min one could detect hyper-responsivity, and with a stress duration of 2 h hypo-responsivity in mutant mouse lines. The present study planned to explore the chemotypic and seasonal variability of the leaf essential oil of A. We also offer a possible explanation for the palatal configuration.

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To obtain quantitative information (e.g., molecular quantity, kinetics, and stoichiometry) within an intact cell, achieving the observation with comparable spatiotemporal resolution is a challenge. In some families, such as chenopods, salt tolerance evolved early in the lineage and has been retained in many lineages. PLM, which induces chloride currents when expressed in Xenopus oocytes, contains consensus phosphorylation sites for both cAMP-dependent protein kinase A and protein kinase C in its cytoplasmic domain. Partially purified preparations were used to study effect of different factors on activities as well as in substrate specificity tests which were conducted using a turbidimetric assay method.

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Concepts and attitudes of parents of adolescents in regard to suicide Physiologic assessment and surgical management of diffuse esophageal spasm.

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Our previous studies have demonstrated that synergistic action of photochemically reactive agents and sunlight produces lethal effects to Paramecium but the protozoan has not received serious consideration for use as an alternative model for phototoxicity evaluation. Furthermore, a protein band is formed in the lower-molecular-weight region. None of the patients had significant complaints and all ankle joints were stable. Comparisons were performed between the values obtained at each abstinence period. These features should be explicitly evaluated in patients with an acute neurological deficit.

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Experience from this study has been used to plan a trial of neoadjuvant chemotherapy with doxorubicin/ifosfamide, which is currently in progress. Developing countries are undergoing demographic transition with a shift from high mortality caused by communicable diseases (CD) to lower mortality rates caused by non-communicable diseases (NCD). Cohort fertility rates, parity fertility rates, age at first birth, first birth intervals, infant mortality, distribution of various contraceptive methods, and contraceptive use by education and number of living children are considered.

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Besides rather obvious merits in gaining more efficient transcription with T7 RNAP, this finding can provide additional insights into regulatory mechanisms of transcription. This first description of a severe, life-threatening asthma attack during prolonged FTY treatment suggests the need for long-term clinical surveillance, especially in patients with known predisposing factors. The fact that the changes in electrical fields at the bone surface are predominantly those originating in the muscles indicates that local electrical phenomena generated by bone strain cannot be the factors initiating the cellular response that is responsible for bone remodeling. Nylon 6,6 is used for biological applications including gastrointestinal segments, tracheal tubes and sutures, vascular graft, and for hard tissue reconstruction.

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Surgical obstructive jaundice (SOJ), followed by abdominal symptoms were the commonest presenting complaints. Chronic Caffeine Administration Attenuates Vascular Injury-Induced Neointimal Hyperplasia in Rats.

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To give an overview of the impact of erosive conditions on the behavior of tooth-colored restoratives and performance of dental adhesives. Antibody responses to various T-independent antigens of B cells with or without C3 receptors and adherent cell requirement for these responses. The aim is to promote the life-saving indications for percutaneous coronary interventions--especially in all forms of acute myocardial infarction. Transient Evoked Otoacoustic Emissions (TEOAEs) were recorded in 15 individuals with ANSD and 22 individuals with normal hearing.

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Advancements of data anomaly detection research in wireless sensor networks: a survey and open issues. Lipids, lipoproteins and apolipoproteins were also correlated with the fasting blood glucose. Autoradiographic study of the cerebrovascular effects of stimulation of the substantia innominata: convenient stimulation paradigm. The molecular subtypes are associated with different risk of metastatic recurrence of the disease. The upper motor neuron syndrome is characterized by symptoms of spastic paresis.

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The classification models based on Elastic Net exhibited high percentage of correct classification, and the discriminant infrared spectra variables extracted provided a good interpretation of the models. Investigation of toxin gene diversity and antimicrobial resistance of Clostridium difficile strains. Treatment of congenital osteopetrosis with high-dose calcitriol.

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Here we show that UV-B, detected by UVR8, provides an unambiguous sunlight signal that inhibits shade avoidance responses in Arabidopsis thaliana by antagonizing the phytohormones auxin and gibberellin. Medicare physician payment reform: changing incentives to maintain access to quality surgical services. The gene products for the mitotic regulator genes RCC1 and Ran, p45rcc1 and p24ran, were expressed in Escherichia coli, purified in large amounts, and characterized for their biochemical properties. Feasibility and acceptability of a collaborative care intervention to improve symptoms and quality of life in chronic heart failure: mixed methods pilot trial.

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In June 2013, two gonorrhoea cases aged 13-14 years, linked to a common source through a social network, were reported. This study shows for the first time that, after a known inciting event, treatment with a compound targeting CB receptors has the potential to prevent the epileptogenic events that result in chronic epileptic damage. The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining.

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A simple technique for the quantitative assessment of gram positivity. Useful aspects of the structure of such a unit are discussed, and case examples are presented. Effects of dietary tryptophan levels on growth, feed/gain, carcass composition and liver glutamate dehydrogenase activity in rainbow trout (Salmo gairdneri).

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International Issues: microfinance in neurologic disorders: a promising role. The data from cardiological departments on renal hypertension in children Electron microscopic localization of two proteins on the surface of the 50 S ribosomal subunit of Escherichia coli using specific antibody markers.

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Different types of diabetes, renal failure, and the time interval since the last vitreous hemorrhage showed no influence on the choice of intraocular tamponades. Clinical meeting of the Brazilian Institute for Study and Research in Gastroenterology Program quality initiatives achieved include the development of a clinical research database, knowledge exchange, performance measurement tools, and health research projects.

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Central changes in nociceptin dynorphin B and Met-enkephalin-Arg-Phe in different models of nociception. It should also be valuable for engineers, psychologists, and researchers using human movements for the development of diagnostic and neuromuscular assessment tools. Early mouse endoderm is patterned by soluble factors from adjacent germ layers.

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Several compounds which most effectively inhibited sulfation without toxic effects on cells were tested for their relative inhibition of sulfation of tyrosine residues (using the fourth component of complement as a model substrate), of N-linked oligosaccharides (alpha 2HS-glycoprotein as substrate), and of proteoglycans. This weight reduction contributed to a significant decrease in systolic blood pressure (SBP) from 157.3 to 137.6 mmHg (P less than 0.005) and diastolic blood pressure (DBP) from 101.1 to 85.2 mmHg (P less than 0.005), which was sustained at two-year follow-up. Endovascular repair of chronic mesenteric occlusive disease: the role of duplex surveillance. If left behind after drainage of the abscess, further operations for removal of retained fecalith or recurrence of abscess might be required.

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This methodology can be easily applied in most wide-field imaging systems. The patient showed an excellent response, so the surgical team completed the treatment with a radical mastectomy and immediate reconstruction with a pedicled latissimus dorsi flap. The crystallographic threefold axis coincides with the symmetry axis of the active molecule, a mushroom-shaped alpha(3)beta(3) hexamer. Cohort study of occupational risk factors of low back pain in construction workers.

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Prognostic factors and treatment effects in patients with curatively resected brain metastasis from colorectal cancer. The blood schizontocidal effect of floxacrine proved superior to that of mefloquine, chloroquine and mepacrine, whereas the causal prophylactic activity was slightly inferior to that of pyrimethamine but superior to that of primaquine. The compounds were identified as stearic acid, palmitic acid and beta-sitosterol. Cerebrospinal fluid and blood cultures of patient confirmed Serratia marcescens (ESBL), resistant pathogen and important nosocomial agent. Micronutrient deficiencies are also more likely to affect breastmilk composition and the development and nutritional status of breastfeeding infants.

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The study results showed that ambulation distances and velocities vary depending on the size of the community and that for individuals to function independently within their community, they must ambulate at velocities and distances much greater than the ambulation objectives that may be set at most rehabilitation settings. In addition, the use of lysates, rather than whole cells, demonstrated that the observed differences in copper binding between the normal and the Menkes fibroblasts were not caused by an abnormality in the membrane transport of copper in the mutant cells. New approaches that take account of contextual as well as individual factors are required. Since rIL-2-mediated activation of the IL-2 receptor and GA-mediated immunomodulation are reported to act through protein kinase C (PKC)-independent pathways, it is concluded that the IL-2 receptor is functional in these dogs and that cell activation through alternative pathways may restore immune responses in affected CSP dogs. Thirty-two cine MR datasets, obtained from 16 healthy females, were analyzed.

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We demonstrated that, in vitro and in vivo, apelin-13 increases the release of these two hormones in a dose-dependent manner. The ThromCat XT is an easy-to-handle, reliable and atraumatic device for the removal of fresh thrombi in native and artificial vessels. Thermometric ammonium ion titration gives more accurate measurement of active chlorine content than iodometric titration. This article reviews the experience to reconstruct skin defects presenting in a coloured ethnic group, by using Keystone flaps, with a review of existing literature. The electrical properties and stability of DNA to UV radiation and aromatic hydrocarbons.

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In an investigation of withdrawals and delays among students enrolled at the University of Tennessee College of Medicine over a four-year period, we found significantly higher rates of attrition among minority than nonminority students and among female than male enrollees. Stress incontinence was corrected in all patients during the period of follow-up.

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Production of long-lived neutralizing antibodies to HIV-1 IIIB in mice with a vaccinia recombinant virus-infected cell vaccine expressing gp160. A total of 513 patients diagnosed as multiple soft tissue contusion in the First Affiliated Hospital of Xinjiang Medical University from January 1, 2008 to January 1, 2013 were retrospectively analyzed. Thus the standardization of pain area documentation permits its application as parameter in research projects with a large number of cases.

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